Advancing Imaging to Enhance Surgery: From Image to Information Guidance

Marco Riva; Egesta Lopci; Lorenzo G Gay; Marco Conti Nibali; Marco Rossi; Tommaso Sciortino; Antonella Castellano; Lorenzo Bello

doi:10.1016/j.nec.2020.08.003

Advancing Imaging to Enhance Surgery: From Image to Information Guidance

Neurosurg Clin N Am. 2021 Jan;32(1):31-46. doi: 10.1016/j.nec.2020.08.003. Epub 2020 Nov 5.

Authors

Marco Riva¹, Egesta Lopci², Lorenzo G Gay³, Marco Conti Nibali⁴, Marco Rossi³, Tommaso Sciortino³, Antonella Castellano⁵, Lorenzo Bello³

Affiliations

¹ Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Via Festa del Perdono 7, Milan 20122, Italy; IRCCS Istituto Ortopedico Galeazzi, U.O. Neurochirurgia Oncologica, Milan, Italy. Electronic address: marco.riva@unimi.it.
² Unit of Nuclear Medicine, Humanitas Clinical and Research Center - IRCCS, Via Manzoni 56, Rozzano, Milan 20089, Italy. Electronic address: https://twitter.com/LopciEgesta.
³ IRCCS Istituto Ortopedico Galeazzi, U.O. Neurochirurgia Oncologica, Milan, Italy; Department of Oncology and Hemato-Oncology, Via Festa del Perdono 7, Milan 20122, Italy.
⁴ IRCCS Istituto Ortopedico Galeazzi, U.O. Neurochirurgia Oncologica, Milan, Italy; Department of Oncology and Hemato-Oncology, Via Festa del Perdono 7, Milan 20122, Italy. Electronic address: https://twitter.com/dr_mcn.
⁵ Neuroradiology Unit and CERMAC, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan 20123, Italy. Electronic address: https://twitter.com/antocastella.

PMID: 33223024
DOI: 10.1016/j.nec.2020.08.003

Abstract

Conventional magnetic resonance imaging (cMRI) has an established role as a crucial disease parameter in the multidisciplinary management of glioblastoma, guiding diagnosis, treatment planning, assessment, and follow-up. Yet, cMRI cannot provide adequate information regarding tissue heterogeneity and the infiltrative extent beyond the contrast enhancement. Advanced magnetic resonance imaging and PET and newer analytical methods are transforming images into data (radiomics) and providing noninvasive biomarkers of molecular features (radiogenomics), conveying enhanced information for improving decision making in surgery. This review analyzes the shift from image guidance to information guidance that is relevant for the surgical treatment of glioblastoma.

Keywords: Glioblastoma; Image guidance; Magnetic resonance imaging (MRI); PET; Presurgical planning; Radiomics; Surgery.

Publication types

Review

MeSH terms

Brain Neoplasms / diagnostic imaging*
Brain Neoplasms / surgery*
Glioblastoma / diagnostic imaging*
Glioblastoma / surgery*
Humans
Neuronavigation
Neurosurgical Procedures*