Bioprocess intensification: Cases that (don't) work

N Biotechnol. 2021 Mar 25:61:108-115. doi: 10.1016/j.nbt.2020.11.007. Epub 2020 Nov 19.

Abstract

Development of affordable and low carbon biobased manufacturing depends critically on strategies that reduce cost and emission profiles. This paper indicates that efforts around the reduction of capital costs by intensification of process equipment need to be carefully weighed against the inherently fast increasing financial and climate costs of driving forces used for the intensification. The fundamental relation between capital expenditures (CAPEX) and operational expenditures (OPEX) of intensified and non-intensified biobased processes and their financial and climatic impacts are emphasized and provisionally explored for a few industrial processes. General learnings flag the importance in particular of OPEX minimisation for sustainable bio-economic development.

Keywords: Bioprocess intensification; Integrated biobased manufacturing; Techno-Economic assessment; Thermodynamic analysis.

MeSH terms

  • Biotechnology / economics*
  • Costs and Cost Analysis / economics*