Breast Implant-Associated Anaplastic Large Cell Lymphoma: Defining Future Research Priorities

Ryan C DeCoster; Evan B Lynch; Alisha R Bonaroti; Roberto N Miranda; Kelly K Hunt; Mark W Clemens

doi:10.1016/j.cps.2020.09.001

Breast Implant-Associated Anaplastic Large Cell Lymphoma: Defining Future Research Priorities

Clin Plast Surg. 2021 Jan;48(1):33-43. doi: 10.1016/j.cps.2020.09.001.

Authors

Ryan C DeCoster¹, Evan B Lynch², Alisha R Bonaroti², Roberto N Miranda³, Kelly K Hunt⁴, Mark W Clemens⁵

Affiliations

¹ Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, 770 Welch Road, Suite 400, Palo Alto, CA 94304, USA. Electronic address: rcdecostermd@gmail.com.
² Division of Plastic and Reconstructive Surgery, University of Kentucky Medical Center, 1000 South Limestone, Lexington, KY 40536, USA.
³ Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard # 853, Houston, TX 77030, USA.
⁴ Department of Breast Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA.
⁵ Department of Plastic and Reconstructive Surgery, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street Unit 1488, Houston, TX 77030, USA.

PMID: 33220903
DOI: 10.1016/j.cps.2020.09.001

Abstract

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an emerging cancer of the immune system that is exclusively associated with textured-surface breast implants. This clinical review provides an update on the diagnosis and management of BIA-ALCL with an emphasis on major advances. The epidemiology and pathophysiology of the disease are also reviewed, focusing on current paradigm shifts and highlighting current controversies related to disease classification and risk mitigation. Finally, the authors conclude by discussing medicolegal and ethical issues surrounding BIA-ALCL while establishing a future basic science and clinical research agenda that is central to improving patient safety.

Keywords: BIA-ALCL; Breast implants; Lymphoma.

Publication types

Review

MeSH terms

Breast / pathology
Breast / surgery
Breast Implants / adverse effects*
Breast Neoplasms / diagnosis
Breast Neoplasms / etiology*
Breast Neoplasms / pathology
Breast Neoplasms / surgery
Female
Humans
Lymphoma, Large-Cell, Anaplastic / diagnosis
Lymphoma, Large-Cell, Anaplastic / etiology*
Lymphoma, Large-Cell, Anaplastic / pathology
Lymphoma, Large-Cell, Anaplastic / surgery
Neoplasm Staging
Research