Is There a Role for Locoregional Therapies for Non-colorectal Gastrointestinal Malignancies?

Gilton Marques Fonseca; Maria Ignez Freitas Melro Braghiroli; Jaime Arthur Pirola Kruger; Fabricio Ferreira Coelho; Paulo Herman

doi:10.1016/j.soc.2020.08.004

Is There a Role for Locoregional Therapies for Non-colorectal Gastrointestinal Malignancies?

Surg Oncol Clin N Am. 2021 Jan;30(1):125-142. doi: 10.1016/j.soc.2020.08.004. Epub 2020 Oct 28.

Authors

Gilton Marques Fonseca¹, Maria Ignez Freitas Melro Braghiroli², Jaime Arthur Pirola Kruger¹, Fabricio Ferreira Coelho¹, Paulo Herman³

Affiliations

¹ Digestive Surgery Division, Liver Surgery Unit, Department of Gastroenterology, University of Sao Paulo Medical School, Avenida Doutor Enéas de Carvalho Aguiar, 255, Instituto Central, 9° andar, Sala 9074, Cerqueira Cesar, São Paulo, São Paulo CEP: 05403-900, Brazil.
² Instituto do Cancer do Estado de Sao Paulo (ICESP), University of Sao Paulo, and Rede D'Or Sao Paulo, Av. Dr. Arnaldo, 251 - São Paulo, SP, Brazil. CEP: 01246-000, Brazil.
³ Digestive Surgery Division, Liver Surgery Unit, Department of Gastroenterology, University of Sao Paulo Medical School, Avenida Doutor Enéas de Carvalho Aguiar, 255, Instituto Central, 9° andar, Sala 9074, Cerqueira Cesar, São Paulo, São Paulo CEP: 05403-900, Brazil. Electronic address: pherman@uol.com.br.

PMID: 33220801
DOI: 10.1016/j.soc.2020.08.004

Abstract

The liver is the most common site of metastases from solid gastrointestinal tract tumors. Over the past few decades, the role of locoregional therapies, resection and thermal ablation, for neuroendocrine and colorectal liver metastases has been widely studied. However, for liver metastases originating from other gastrointestinal organs, the role of locoregional treatment remains unclear. This review summarizes and discusses the available evidence regarding benefits, risks, and indications for locoregional therapies for non-colorectal and non-neuroendocrine gastrointestinal liver metastases, highlighting the importance of multidisciplinary approach and patient selection.

Keywords: Gastrointestinal cancer; Hepatectomy; Liver; Metastases; Treatment.

Publication types

Review

MeSH terms

Colorectal Neoplasms* / therapy
Gastrointestinal Neoplasms* / therapy
Hepatectomy
Humans
Liver Neoplasms* / surgery
Patient Selection