An Overview of Liver Directed Locoregional Therapies

Diederik J Höppener; Dirk J Grünhagen; Alexander M M Eggermont; Astrid A M van der Veldt; Cornelis Verhoef

doi:10.1016/j.soc.2020.09.001

An Overview of Liver Directed Locoregional Therapies

Surg Oncol Clin N Am. 2021 Jan;30(1):103-123. doi: 10.1016/j.soc.2020.09.001.

Authors

Diederik J Höppener¹, Dirk J Grünhagen¹, Alexander M M Eggermont², Astrid A M van der Veldt³, Cornelis Verhoef⁴

Affiliations

¹ Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.
² Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, the Netherlands.
³ Department of Medical Oncology, Erasmus MC Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.
⁴ Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands. Electronic address: c.verhoef@erasmusmc.nl.

PMID: 33220800
DOI: 10.1016/j.soc.2020.09.001

Abstract

An overview of all liver-directed locoregional therapies, including surgical resection for melanoma liver metastases (MLMs), is provided. MLM patients are divided by their primary melanoma location; cutaneous, uvea (eye), and mucosal melanoma. If patients with isolated cutaneous MLMs are considered for surgical resection, treatment with systemic therapy should be part of the treatment course. For uveal MLMs, complete surgical or ablative treatment of all MLMs suggests superior results compared with other liver-directed or systemic therapies, based on current evidence, no recommendations for any liver-directed regional therapy in the treatment of mucosal MLMs can be made.

Keywords: Cutaneous melanoma; Liver directed therapy; Liver metastasis; Local therapy; Mucosal melanoma; Surgery; Systematic review; Uveal melanoma.

Publication types

Review

MeSH terms

Humans
Liver Neoplasms* / therapy
Melanoma* / therapy
Uveal Neoplasms*