Normal Somatic Mutations in Cancer Transformation

Neshika Wijewardhane; Lisa Dressler; Francesca D Ciccarelli

doi:10.1016/j.ccell.2020.11.002

Normal Somatic Mutations in Cancer Transformation

Cancer Cell. 2021 Feb 8;39(2):125-129. doi: 10.1016/j.ccell.2020.11.002. Epub 2020 Nov 20.

Authors

Neshika Wijewardhane¹, Lisa Dressler², Francesca D Ciccarelli³

Affiliations

¹ Cancer Systems Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
² Cancer Systems Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK; Department of Medical and Molecular Genetics, King's College London, London WC2R 2LS, UK.
³ Cancer Systems Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK. Electronic address: francesca.ciccarelli@crick.ac.uk.

PMID: 33220180
DOI: 10.1016/j.ccell.2020.11.002

Abstract

Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understanding of tumorigenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carcinogenesis / genetics*
Carcinogenesis / pathology*
Cell Transformation, Neoplastic / genetics*
Cell Transformation, Neoplastic / pathology*
Gene Expression Regulation, Neoplastic / genetics
Humans
Mutation / genetics*
Neoplasms / genetics*
Neoplasms / pathology*

Abstract

Publication types

MeSH terms

Grants and funding