Abstract
Epidemiology of bat Betacoronavirus, subgenus Sarbecovirus is largely unknown, especially outside China. We detected a sarbecovirus phylogenetically related to severe acute respiratory syndrome coronavirus 2 from Rhinolophus cornutus bats in Japan. The sarbecovirus' spike protein specifically recognizes angiotensin-converting enzyme 2 of R. cornutus, but not humans, as an entry receptor.
Keywords:
COVID-19; Japan; Rhinolophus cornutus; SARS; SARS-CoV-2; bat sarbecovirus; betacoronavirus; coronavirus; coronavirus disease; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiotensin-Converting Enzyme 2 / metabolism
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Animals
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Betacoronavirus / genetics*
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Betacoronavirus / physiology
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Chiroptera / virology*
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Coronavirus Infections / epidemiology
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Coronavirus Infections / veterinary*
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Coronavirus Infections / virology
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HEK293 Cells
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Humans
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Japan / epidemiology
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Phylogeny
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SARS-CoV-2 / genetics
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SARS-CoV-2 / physiology
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Spike Glycoprotein, Coronavirus / genetics
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Spike Glycoprotein, Coronavirus / metabolism
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Virus Internalization
Substances
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Spike Glycoprotein, Coronavirus
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spike protein, SARS-CoV-2
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Angiotensin-Converting Enzyme 2