Roles of Tet2 in meiosis, fertility and reproductive aging

Huasong Wang; Linlin Liu; Mo Gou; Guian Huang; Chenglei Tian; Jiao Yang; Haiying Wang; Qin Xu; Guo Liang Xu; Lin Liu

doi:10.1007/s13238-020-00805-8

Roles of Tet2 in meiosis, fertility and reproductive aging

Protein Cell. 2021 Jul;12(7):578-585. doi: 10.1007/s13238-020-00805-8. Epub 2020 Nov 20.

Authors

Huasong Wang^#^{1

2}, Linlin Liu^#^{1

2}, Mo Gou^#^{1

2}, Guian Huang^{1

2}, Chenglei Tian^{1

2}, Jiao Yang^{1

2}, Haiying Wang^{1

2}, Qin Xu³, Guo Liang Xu^{3

4}, Lin Liu^{5

6}

Affiliations

¹ Department of Cell Biology and Genetics, College of Life Sciences, Nankai University, Tianjin, 300071, China.
² State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
³ State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
⁴ Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
⁵ Department of Cell Biology and Genetics, College of Life Sciences, Nankai University, Tianjin, 300071, China. liulin@nankai.edu.cn.
⁶ State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. liulin@nankai.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter

MeSH terms

Aging / genetics*
Animals
Ataxia Telangiectasia Mutated Proteins / genetics
Ataxia Telangiectasia Mutated Proteins / metabolism
BRCA2 Protein / genetics
BRCA2 Protein / metabolism
Cell Cycle Proteins / genetics
Cell Cycle Proteins / metabolism
DNA-Binding Proteins / deficiency
DNA-Binding Proteins / genetics*
DNA-Binding Proteins / metabolism
Dioxygenases / deficiency
Dioxygenases / genetics*
Embryo, Mammalian
Female
Fertility / genetics*
Fetus
Gene Expression Profiling
Gene Expression Regulation, Developmental
Gene Ontology
Homozygote
Inhibitor of Differentiation Proteins / genetics
Inhibitor of Differentiation Proteins / metabolism
Meiosis
Mice
Mice, Knockout
Molecular Sequence Annotation
Oocytes / cytology
Oocytes / growth & development
Oocytes / metabolism*
Ovary / cytology
Ovary / growth & development
Ovary / metabolism*
Phosphate-Binding Proteins / genetics
Phosphate-Binding Proteins / metabolism
Reproduction / genetics*

Substances

BRCA2 Protein
BRCA2 protein, mouse
Cell Cycle Proteins
DNA-Binding Proteins
Dmc1 protein, mouse
Inhibitor of Differentiation Proteins
Phosphate-Binding Proteins
Sycp3 protein, mouse
Idb3 protein, mouse
Dioxygenases
Tet2 protein, mouse
Ataxia Telangiectasia Mutated Proteins
Atm protein, mouse