Toxoplasmosis Related Neuroretinitis: More than Meets the Eye

Ocul Immunol Inflamm. 2022 Apr 3;30(3):556-559. doi: 10.1080/09273948.2020.1821896. Epub 2020 Nov 20.

Abstract

Background: The intracellular protozoan Toxoplasma (T. gondii) is a parasitic infection, normally asymptomatic in immunocompetent patients. It often manifests ophthalmically, with focal necrotizing retinitis, and is more rarely associated with vitritis and anterior uveitis. Neuroretinitis, which results in severe, painless visual loss, optic disc edema, and a macular star, is an unusual first presentation of toxoplasmosis which despite being rare, when it does occur tends to affect young, immunosuppressed patients.

Case presentation: This case report describes a 34-year-old, white, European, immunocompetent female, who developed sudden visual loss and was found to have optic disc edema and stellate macular exudates. She was managed in an ophthalmic unit in the UK, a country with a low prevalence of toxoplasmosis Following extensive investigation, confirming Toxoplasma the standard anti-toxoplasmosis treatment was commenced, resulting in visual improvement over the following 6 months.

Conclusion: Toxoplasmic neuroretinitis should be considered with no background of systemic illness and in the absence of classical risk factors.

Keywords: Immunocompetent; Toxoplasma gondii; macular star; neuroretinitis; stellate macular exudates; toxoplasmosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Eye Infections, Parasitic* / complications
  • Eye Infections, Parasitic* / diagnosis
  • Female
  • Fundus Oculi
  • Humans
  • Papilledema* / diagnosis
  • Papilledema* / etiology
  • Retinitis* / diagnosis
  • Retinitis* / drug therapy
  • Toxoplasma*
  • Vision Disorders
  • Visual Acuity