Novel Application for G Protein-Biased Mu Opioid Receptor Agonists in Opioid Relapse Prevention

Biol Psychiatry. 2020 Dec 15;88(12):896-897. doi: 10.1016/j.biopsych.2020.09.006.

Authors

Amanda K Fakira¹, Lakshmi A Devi², Pamela J Kennedy³

Affiliations

¹ Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, New Jersey.
² Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: lakshmi.devi@mssm.edu.
³ Department of Psychology and Brain Research Institute, University of California, Los Angeles, California.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Analgesics, Opioid*
Animals
GTP-Binding Proteins / metabolism
Hypoxia, Brain*
Oxycodone
Rats
Receptors, Opioid, mu / metabolism
Recurrence
Secondary Prevention
Spiro Compounds
Thiophenes

Substances

((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine
Analgesics, Opioid
Receptors, Opioid, mu
Spiro Compounds
Thiophenes
Oxycodone
GTP-Binding Proteins

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