Salzmann's nodular degeneration

Kevin Wang; Craig W See

doi:10.1016/j.exer.2020.108351

Salzmann's nodular degeneration

Exp Eye Res. 2021 Jan:202:108351. doi: 10.1016/j.exer.2020.108351. Epub 2020 Nov 16.

Authors

Kevin Wang¹, Craig W See²

Affiliations

¹ Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
² Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: seec@ccf.org.

PMID: 33212141
DOI: 10.1016/j.exer.2020.108351

Abstract

Salzmann nodular corneal degeneration is a non-inflammatory, progressive corneal degeneration characterized by bluish-white nodules of varying shapes classically located in the mid-peripheral cornea. It was first described by Maximilian Salzmann in 1925 and was noted at that time to be associated with "eczematous keratoconjunctivitis". Since then, significant progress has been made to understand environmental and genetic risk factors associated with SND. However, etiopathogenesis remains poorly understood. A review of the literature was performed to highlight our recent understanding of SND and its management.

Keywords: Salzmann; Salzmann nodular corneal degeneration; Salzmann's nodule.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cornea / pathology*
Corneal Dystrophies, Hereditary / pathology*
Humans
Visual Acuity*