Cytotoxic ergostane-type steroids from Ganoderma lingzhi

Steroids. 2021 Jan:165:108767. doi: 10.1016/j.steroids.2020.108767. Epub 2020 Nov 16.

Abstract

Two new ergostane-type steroids (1 and 2) have been isolated from the fruiting body of a medicinal macro fungus Ganoderma lingzhi. The structures including the absolute configurations of them were elucidated by a combination of different spectroscopic analyses especially 13C NMR and ECD calculations. Compound 2 features an unusual 1,2-dioxolane moiety. Our bioassays revealed that the two steroids showed remarkable cytotoxicity against human A549 (lung) and MCF-7 (breast) tumor cell lines, with IC50 values ranging from 5.15 to 8.57 μg/mL.

Keywords: Cytotoxicity; Ergostane; Ganoderma lingzhi; Lingzhi; Steroids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents
  • Cell Line, Tumor
  • Ergosterol / analogs & derivatives*
  • Fruiting Bodies, Fungal
  • Ganoderma
  • Humans
  • Steroids

Substances

  • Antineoplastic Agents
  • Steroids
  • ergostane
  • Ergosterol