The Wolfson Medical Center was established forty years ago, in 1980, with the aim of providing residents of the surrounding cities with medical services of international standards. It has about 700 hospital beds. The population served by the Wolfson Medical Center numbers about one million residents, from the cities of Bat Yam, Holon, Rishon Lezion and Tel Aviv-Yafo. This population is very diverse, and includes patients of a wide age range, residents of all religions and cultures, religious and secular, people of socioeconomic and educational status from a broad spectrum, foreign workers, refugees and residents of countries from all over the world. This diversity reflects the unique challenges facing Wolfson Medical Center. As part of the activities of "Save a Child's Heart" over 5,000 children with congenital heart defects from 65 countries around the world have been operated on in Wolfson in the last 25 years. As part of the joint work with "Save a Child's Heart", the new Children's Hospital will be opened in the coming months. In this issue, we will present works that reflect the diversity of clinical and research work at the medical center.