Poorly Differentiated Neuroendocrine Tumor With 18F-Fluciclovine Uptake in a Patient With Metastatic Castrate-Resistant Prostate Cancer

Clin Nucl Med. 2021 May 1;46(5):e282-e285. doi: 10.1097/RLU.0000000000003408.

Abstract

18F-Fluciclovine is an amino acid-based radiopharmaceutical used primarily for PET imaging of patients with biochemical recurrence of prostate cancer. We report a case of a 66-year-old man with recently diagnosed metastatic castrate-resistant prostate cancer and a left supraclavicular lymph node with incidental radiotracer uptake on 18F-fluciclovine PET/CT. Left neck core needle biopsy confirmed high-grade, poorly differentiated carcinoma with neuroendocrine features positive for synaptophysin and chromogranin, and negative for prostate markers.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biological Transport
  • Carboxylic Acids / metabolism*
  • Cyclobutanes / metabolism*
  • Humans
  • Male
  • Neuroendocrine Tumors / diagnostic imaging
  • Neuroendocrine Tumors / metabolism*
  • Neuroendocrine Tumors / pathology
  • Neuroendocrine Tumors / secondary*
  • Positron Emission Tomography Computed Tomography*
  • Prostatic Neoplasms, Castration-Resistant / pathology*

Substances

  • Carboxylic Acids
  • Cyclobutanes
  • fluciclovine F-18