Foxp3 Re-distributes Its Heavy Lifting

Aditi Chandra; Naomi Goldman; Golnaz Vahedi

doi:10.1016/j.immuni.2020.10.021

Foxp3 Re-distributes Its Heavy Lifting

Immunity. 2020 Nov 17;53(5):895-897. doi: 10.1016/j.immuni.2020.10.021.

Authors

Aditi Chandra¹, Naomi Goldman¹, Golnaz Vahedi²

Affiliations

¹ Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
² Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: vahedi@pennmedicine.upenn.edu.

PMID: 33207211
DOI: 10.1016/j.immuni.2020.10.021

Abstract

Understanding the mechanisms that establish regulatory T (Treg) cell identity is central to understanding Treg cell function. van der Veeken et al. now show that the lineage-determining transcription factor Foxp3 establishes Treg-cell-specific chromatin architecture indirectly, mostly by decreasing the expression of other transcriptional regulators, including TCF1.

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MeSH terms

Chromatin
Forkhead Transcription Factors* / genetics
Forkhead Transcription Factors* / metabolism
Gene Expression Regulation
Lifting
T-Lymphocytes, Regulatory* / metabolism

Substances

Chromatin
Forkhead Transcription Factors