Frontiers in non-union research

Enrique Gómez-Barrena; Norma G Padilla-Eguiluz; Philippe Rosset

doi:10.1302/2058-5241.5.190062

Frontiers in non-union research

EFORT Open Rev. 2020 Oct 26;5(10):574-583. doi: 10.1302/2058-5241.5.190062. eCollection 2020 Oct.

Authors

Enrique Gómez-Barrena¹, Norma G Padilla-Eguiluz¹, Philippe Rosset²

Affiliations

¹ Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain.
² Service de Chirurgie Orthopédique et Traumatologie, CHU Tours, Université de Tours, Tours, France.

Abstract

Multifactorial aetiology defines non-unions, with a biological and a mechanical distortion of the timeline of bone healing.Research on new advances to increase osteogenesis and promote non-union healing is strongly directed towards new forms of cell products.Basic science and research on non-union treatments is needed to compile preclinical data on new treatments.Bone marrow concentration and expanded mesenchymal stromal cells still require extensive clinical research to confirm efficacy in non-union treatment.Solid preclinical studies, precise cell product definition and preparation, and appropriate ethical and regulatory approvals are needed to assess new advanced therapy medicinal products. Cite this article: EFORT Open Rev 2020;5:574-583. DOI: 10.1302/2058-5241.5.190062.

Keywords: ATMPs (advanced therapy medicinal products); MSCs (mesenchymal stromal cells) and biomaterials; bone healing; cell therapy; non-union.

Publication types

Review