Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective

Zhaoping Wang; Xiaolin Ni; Li Zhang; Liang Sun; Xiaoquan Zhu; Qi Zhou; Ze Yang; Huiping Yuan

doi:10.2147/DMSO.S279104

Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective

Diabetes Metab Syndr Obes. 2020 Nov 10:13:4261-4272. doi: 10.2147/DMSO.S279104. eCollection 2020.

Authors

Zhaoping Wang¹, Xiaolin Ni^{1

2}, Li Zhang¹, Liang Sun¹, Xiaoquan Zhu¹, Qi Zhou¹, Ze Yang¹, Huiping Yuan¹

Affiliations

¹ The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
² Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Abstract

Patients with type-2 diabetes mellitus (T2DM) display chronic low-grade inflammation induced by activation of the innate immune system. Toll-like receptor (TLR)4 is a pattern recognition receptor that plays a vital part in activation of the innate immune system. Results from animal and computer-simulation studies have demonstrated that targeting TLR4 to block the TLR4-nuclear factor-kappa B (NF-κB) pathway reduces the inflammatory response and complications associated with T2DM. Therefore, TLR4-targeted therapy has broad prospects. Here, we reviewed the role of TLR4 in inflammation during chronic hyperglycemia in T2DM and its therapeutic prospects.

Keywords: T2DM; TLR4; TLR4 treatment; TLRS; inflammation.

Publication types

Review