A New Type of MgFe2O4@CuS-APTES Nanocarrier for Magnetic Targeting and Light-Microwave Dual Controlled Drug Release

Int J Nanomedicine. 2020 Nov 10:15:8783-8802. doi: 10.2147/IJN.S267614. eCollection 2020.

Abstract

Introduction: Cancer is a major health problem worldwide, and the most extensive treatment can be obtained by using chemotherapy in the clinic. However, due to the low selectivity of cancer cells, chemotherapy drugs produce a series of grievous side effects on normal cells.

Methods: In this research, we developed novel nanocarriers for magnetically targeted near-infrared (NIR) light-electromagnetic wave dual controlled drug delivery based on MgFe2O4@CuS nanoparticles (NPs) modified with aminopropyltriethoxysilane (APTES) in response to magnetic, NIR light, and electromagnetic wave irradiation. Synthesis and characterization of MgFe2O4@CuS-APTES NPs was carried out using X-ray diffraction measurements, scanning electron microscopy, transmission electron microscopy, photoluminescence emission spectra, UV-1800 spectrophotometer, N5230A vector network analyzer, MDS-6 microwave sample preparation system, and superconducting quantum interference device. In addition to that mentioned above, we also explored many other sides, such as the drug-loading, drug-controlled release efficiency, elect99omagnetic wave thermal effect and photo-thermal effect.

Results: The results showed that APTES-modified MgFe2O4@CuS NPs had 37% high drug-loading capacity and high electromagnetic wave thermal conversion ability and NIR-light thermal conversion ability. In addition, ibuprofen (IBU) release from the MgFe2O4@CuS-APTES-IBU depends on the electromagnetic wave (2.45 GHz) and 1060 nm NIR light irradiation. After five cycles, the drug-release percentage was 90% and 66% separately, and could be adjusted by the time and cycles times of electromagnetic wave and NIR light irritation. Electromagnetic wave irradiation compared with NIR light irradiation, has a higher drug release rate and better penetration. Therefore, choosing different stimulation methods according to the treatment needs of the disease, we can achieve accurate personalized treatment of the disease.

Discussion: Our findings indicate that multifunctional APTES modified MgFe2O4@CuS NPs could be used for the first time as a new drug carrier for "location-timing-quantification" drug release with magnetic targeting and dual control of NIR light-electromagnetic waves.

Keywords: MgFe2O4@CuS; NIR light-electromagnetic wave heat conversion property; dual controlled release; magnetic targeting.

MeSH terms

  • Copper / chemistry*
  • Delayed-Action Preparations
  • Drug Carriers / chemistry*
  • Ferric Compounds / chemistry*
  • Humans
  • Light*
  • Magnesium Compounds / chemistry*
  • Magnetic Phenomena*
  • Microwaves*
  • Nanoparticles / chemistry
  • Neoplasms / drug therapy
  • Propylamines / chemistry*
  • Silanes / chemistry*

Substances

  • Delayed-Action Preparations
  • Drug Carriers
  • Ferric Compounds
  • Magnesium Compounds
  • Propylamines
  • Silanes
  • magnesium ferrite
  • Copper
  • cupric sulfide
  • amino-propyl-triethoxysilane

Grants and funding

This work was supported by National Natural Science Foundation of China (grant number 51704116); Hunan Province Natural Science Foundation of China (grant numbers 2018JJ3252; 2017JJ3123); the scientific research project of Hunan Province, Department of Education (grant numbers 19A264; 18B457; 18C0886); the planned science and technology project of Hunan Province, China (grant number 2016TP1028); the double first-class discipline construction program of Hunan Province and China postdoctoral science foundation (grant number 2017M 612582).