Cerebrospinal fluid IL-1β is elevated in tuberculous meningitis patients but not associated with mortality

Tuberculosis (Edinb). 2021 Jan:126:102019. doi: 10.1016/j.tube.2020.102019. Epub 2020 Nov 11.

Abstract

Inflammation contributes to the pathophysiology and high mortality of tuberculous meningitis. The IL-1β pathway has been implicated in immunopathology and could be a target for host-directed therapy. IL-1β was elevated in the cerebrospinal fluid (CSF) of 225 HIV-uninfected tuberculous meningitis patients in Indonesia compared to controls, but did not predict subsequent mortality, nor did IL-6 or IL-1Ra. Furthermore, genetic loci known to regulate IL1B gene expression did not predict mortality in 443 tuberculous meningitis patients, although two of these loci did predict CSF IL-1β concentrations. Collectively, these data argue against a role for IL-1β targeted host-directed therapy in tuberculous meningitis.

Keywords: Interleukin-1β; Mortality; Tuberculous meningitis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / cerebrospinal fluid
  • Female
  • Follow-Up Studies
  • Humans
  • Indonesia / epidemiology
  • Interleukin 1 Receptor Antagonist Protein / cerebrospinal fluid*
  • Male
  • Mycobacterium tuberculosis / isolation & purification*
  • Prospective Studies
  • Survival Rate / trends
  • Tuberculosis, Meningeal / cerebrospinal fluid*
  • Tuberculosis, Meningeal / microbiology
  • Tuberculosis, Meningeal / mortality
  • Young Adult

Substances

  • Biomarkers
  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein