Prothrombotic hemostasis disturbances in patients with severe COVID-19: Individual daily data

Michaël Hardy; Isabelle Michaux; Sarah Lessire; Jonathan Douxfils; Jean-Michel Dogné; Marion Bareille; Geoffrey Horlait; Pierre Bulpa; Celine Chapelle; Silvy Laporte; Sophie Testa; Hugues Jacqmin; Thomas Lecompte; Alain Dive; François Mullier

doi:10.1016/j.dib.2020.106519

Prothrombotic hemostasis disturbances in patients with severe COVID-19: Individual daily data

Data Brief. 2020 Dec:33:106519. doi: 10.1016/j.dib.2020.106519. Epub 2020 Nov 10.

Authors

Michaël Hardy^{1

2}, Isabelle Michaux³, Sarah Lessire², Jonathan Douxfils^{4

5}, Jean-Michel Dogné⁴, Marion Bareille¹, Geoffrey Horlait³, Pierre Bulpa³, Celine Chapelle^{6

7}, Silvy Laporte^{6

7}, Sophie Testa⁸, Hugues Jacqmin¹, Thomas Lecompte⁹, Alain Dive³, François Mullier¹

Affiliations

¹ Université catholique de Louvain, CHU UCL Namur, Hematology Laboratory, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS), Yvoir, Belgium.
² Université catholique de Louvain, CHU UCL Namur, Anesthesiology Department, Namur Thrombosis and hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS), Yvoir, Belgium.
³ Université catholique de Louvain, CHU UCL Namur, Department of Intensive Care, Yvoir, Belgium.
⁴ Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium.
⁵ Qualiblood s.a., Namur, Belgium.
⁶ Unité de Recherche Clinique, Innovation, Pharmacologie, CHU Saint-Etienne, Hôpital Nord, F-42055 Saint-Etienne, France.
⁷ SAINBIOSE U1059, Université Jean Monnet, University Lyon, INSERM, F-CRIN INNOVTE Network, F-42023 Saint-Etienne, France.
⁸ Haemostasis and Thrombosis Center, Cremona Hospital, Cremona, Italy.
⁹ Département de Médecine, Hôpitaux Universitaires de Genève, service d'angiologie et d'hémostase et Faculté de Médecine, Geneva Platelet Group (GpG), Université de Genève, Geneva, Switzerland.

Abstract

This data article accompanies the manuscript entitled: "Prothrombotic Disturbances of hemostasis of Patients with Severe COVID-19: a Prospective Longitudinal Observational Cohort Study" submitted to Thrombosis Research by the same authors. We report temporal changes of plasma levels of an extended set of laboratory parameters during the ICU stay of the 21 COVID-19 patients included in the monocentre cohort: CRP, platelet count, prothrombin time; Clauss fibrinogen and clotting factors II, V and VIII levels, D-dimers, antithrombin activity, protein C, free protein S, total and free tissue factor pathway inhibitor, PAI-1 levels, von Willebrand factor antigen and activity, ADAMTS-13 (plasma levels); and of two integrative tests of coagulation (thrombin generation with ST Genesia) and fibrinolysis (global fibrinolytic capacity - GFC). Regarding hemostasis, we used double-centrifuged frozen citrated plasma prospectively collected after daily performance of usual coagulation tests. Demographic and clinical characteristics of patients and thrombotic and hemorrhagic complications were also collected from patient's electronic medical reports.

Keywords: COVID-19; D-dimers; Fibrinolysis; Hemostasis plasma proteins; Intensive care unit; Thrombin generation; Thrombosis.