Association between donor/recipient MTRR gene polymorphisms and the risk of new-onset neurological complications after liver transplantation

Haojun Wang; Huan Liu; Xin Wang; Feng Wang; Qingguo Xu; Tongwang Yang; Ge Guan; Yong Zhang; Yandong Sun; Cunle Zhu; Xinqiang Li; Yunjin Zang

doi:10.1016/j.jneuroim.2020.577438

Association between donor/recipient MTRR gene polymorphisms and the risk of new-onset neurological complications after liver transplantation

J Neuroimmunol. 2020 Nov 7:350:577438. doi: 10.1016/j.jneuroim.2020.577438. Online ahead of print.

Authors

Haojun Wang¹, Huan Liu², Xin Wang², Feng Wang², Qingguo Xu², Tongwang Yang², Ge Guan², Yong Zhang², Yandong Sun², Cunle Zhu³, Xinqiang Li³, Yunjin Zang⁴

Affiliations

¹ Qingdao University, Qingdao, CN 266071, China; The Affiliated Hospital of Qingdao University, Qingdao, CN 266003, China.
² The Affiliated Hospital of Qingdao University, Qingdao, CN 266003, China.
³ Qingdao University, Qingdao, CN 266071, China.
⁴ The Affiliated Hospital of Qingdao University, Qingdao, CN 266003, China. Electronic address: zangyj3657@qq.com.

PMID: 33197842
DOI: 10.1016/j.jneuroim.2020.577438

Abstract

Neurological complications are very common after liver transplantation. This study focuses on clinical risk factors and susceptibility gene polymorphisms of neurological complications after liver transplantation. A better predictive model is obtained. This study proves that MTRR is an independent susceptibility gene for neurological complications. Compared with the independent risk factor of abdominal infection, MTRR has a more advantageous value in predicting neurological complications after liver transplantation.

Keywords: Liver transplantation; MTRR gene polymorphisms; New-onset neurological complications.