Serum and Urinary N-Terminal Pro-brain Natriuretic Peptides as Biomarkers for Bronchopulmonary Dysplasia of Preterm Neonates

Zoi Iliodromiti; Evangelos Christou; Nikolaos Vrachnis; Rozeta Sokou; Dionysios Vrachnis; Georgia Mihopoulou; Theodora Boutsikou; Nicoletta Iacovidou

doi:10.3389/fped.2020.588738

Serum and Urinary N-Terminal Pro-brain Natriuretic Peptides as Biomarkers for Bronchopulmonary Dysplasia of Preterm Neonates

Front Pediatr. 2020 Oct 28:8:588738. doi: 10.3389/fped.2020.588738. eCollection 2020.

Authors

Zoi Iliodromiti¹, Evangelos Christou¹, Nikolaos Vrachnis^{2

3}, Rozeta Sokou⁴, Dionysios Vrachnis⁵, Georgia Mihopoulou⁶, Theodora Boutsikou¹, Nicoletta Iacovidou¹

Affiliations

¹ Neonatal Department, Aretaieio Hospital, Medical School of National and Kapodistrian University of Athens, Athens, Greece.
² Third Obstetrics and Gynecology Department, Attikon Hospital, Medical School of National and Kapodistrian University of Athens, Athens, Greece.
³ Molecular and Clinical Sciences Research Institute, St George's University of London, London, United Kingdom.
⁴ NICU, "Agios Panteleimon" General Hospital of Nikaia, Piraeus, Greece.
⁵ Endocrinology Unit, Second Obstetrics and Gynecology Department, Aretaieio Hospital, Medical School of National and Kapodistrian University of Athens, Athens, Greece.
⁶ Second Obstetrics and Gynecology Department, Aretaieio Hospital, Medical School of National and Kapodistrian University of Athens, Athens, Greece.

Abstract

Bronchopulmonary dysplasia (BPD) is a common cause of respiratory illness in preterm newborns with high morbidity and mortality rates. At present, there are no early prognostic biomarkers that can be used in clinical practice to predict the development of BPD. In this review, we critically appraise evidence regarding the use of serum N-terminal pro-brain natriuretic peptide (NTproBNP) levels as a biomarker for BPD in neonates. Furthermore, we summarize studies assessing the feasibility of urinary NTproBNP levels as a non-invasive method to predict BPD in preterm infants. Multiple studies reported a strong association between NTproBNP serum levels and the onset of BPD. For urinary NTproBNP there is scarce evidence showing an association with BPD. Given the promising data obtained by preliminary studies, further assessment of this biomarker in both serum and urine is needed. Standardized reference values should be defined before conducting any further clinical studies.

Keywords: biomarker; brain; bronchopulmonary dysplasia; preterm neonate; serum NTproBNP; urinary NTproBNP.

Publication types

Review