PROCOAC (PROspective COhort of A Coruña) description: Spanish prospective cohort to study osteoarthritis

Natividad Oreiro-Villar; Ana C Raga; Ignacio Rego-Pérez; Sonia Pértega; Maite Silva-Diaz; Mercedes Freire; Carlos Fernández-López; Francisco J Blanco

doi:10.1016/j.reuma.2020.08.010

PROCOAC (PROspective COhort of A Coruña) description: Spanish prospective cohort to study osteoarthritis

Reumatol Clin (Engl Ed). 2020 Nov 12:S1699-258X(20)30231-X. doi: 10.1016/j.reuma.2020.08.010. Online ahead of print.

[Article in English, Spanish]

Authors

Natividad Oreiro-Villar¹, Ana C Raga¹, Ignacio Rego-Pérez², Sonia Pértega³, Maite Silva-Diaz⁴, Mercedes Freire¹, Carlos Fernández-López¹, Francisco J Blanco⁵

Affiliations

¹ Servicio de Reumatología, Instituto de Investigación Biomédica de A Coruña, Complexo Hospitalario Universitario de A Coruña, Sergas. Universidade da Coruña, La Coruña, España.
² Grupo de Genómica, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, Universidade da Coruña, La Coruña, España.
³ Unidad de Epidemiología Clínica y Bioestadística, Instituto de Investigación Biomédica de A Coruña, Complexo Hospitalario Universitario de A Coruña, Sergas, Universidade da Coruña, La Coruña, España.
⁴ Servicio de Reumatología, Instituto de Investigación Biomédica de A Coruña, Complexo Hospitalario Universitario de A Coruña, Sergas. Universidade da Coruña, La Coruña, España; Grupo de Genómica, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, Universidade da Coruña, La Coruña, España; Unidad de Epidemiología Clínica y Bioestadística, Instituto de Investigación Biomédica de A Coruña, Complexo Hospitalario Universitario de A Coruña, Sergas, Universidade da Coruña, La Coruña, España.
⁵ Servicio de Reumatología, Instituto de Investigación Biomédica de A Coruña, Complexo Hospitalario Universitario de A Coruña, Sergas. Universidade da Coruña, La Coruña, España. Electronic address: fblagar@sergas.es.

PMID: 33191152
DOI: 10.1016/j.reuma.2020.08.010

Abstract

Introduction and objective: The use of well characterized osteoarthritis cohorts is mandatory for the study and knowledge of this disease. Currently, there is no prospective cohort in this pathology in Spain. The objective of this work is to describe the first osteoarthritis cohort in Spain, PROCOAC (Cohort PROspectiva de A Coruña).

Methods: The Unit of Rheumatology of the University Hospital of A Coruña started a prospective follow-up study in 2006. The patient inclusion criteria were: a) patients older than 55 years who underwent an abdominal x-ray to study both hips; b) patients diagnosed with radiographic hand osteoarthritis according to ACR criteria; c) patients diagnosed with radiographic knee or hip osteoarthritis according to ACR criteria. Follow-up was performed every 2years collecting clinical, analytical, genetic and radiographic information.

Results: The cohort consists of 937 patients, 873 have radiographic knee osteoarthritis, 783 hip osteoarthritis and 679 hand osteoarthritis. The mean age of the population is 63.9±8.9 years and the average BMI is 29.6±5.1. More than half of the population has high blood pressure and 17% diabetes. The predominant osteoarthritis in the hand is nodular (78.1%), followed by trapeziometacarpal (55.3%) and erosive (18.4%). Of them, 21.4% and 43.1% are healthy at knee and hip level respectively; observing a grade 1 in 26% and 37%; a grade 2 in 26.7% and 11.5%; a grade 3 in 14.9% and 4%; and a grade 4 in 9.4% and 3.7%, respectively. Of the population, 44.1% has only one joint affected, 39.9% has 2 and 13.4% has 3 joints affected. Age (OR=1.11; P <.001), BMI (OR=1.11; P=.002) and total WOMAC (OR=1.03; P=.005) are the only risk factors if we compare the involvement of a single location versus 3. A discrepancy between pain and radiographic damage at the joint level was also detected in patients with KL ≤ 2 grade, and therefore a significantly higher percentage of patients with knee osteoarthritis experienced pain (66.1%) compared to patients with osteoarthritis hip (21.1%) (P<.001).

Conclusions: The PROCOAC cohort is an instrument that allows studies of incidence and progression in hand, knee and hip osteoarthritis; as well as determining factors that are associated with the different osteoarthritis phenotypes.

Keywords: Cohort; Cohorte; Osteoarthritis; Osteoartritis; PROCOAC.