Effects of cocoa-rich chocolate on cognitive performance in postmenopausal women. A randomised clinical trial

Nutr Neurosci. 2022 Jun;25(6):1147-1158. doi: 10.1080/1028415X.2020.1840119. Epub 2020 Nov 15.

Abstract

Objectives: The aim of this research was to evaluate the effects of adding 10 g of cocoa-rich chocolate (99%) to the habitual diet on cognitive performance in postmenopausal women.

Methods: Following a randomised controlled parallel clinical trial, a total of 140 postmenopausal women aged 50-64 were recruited. The intervention group (n = 73) consumed daily 10 g of chocolate (99% cocoa) in addition to their usual food intake for 6 months, whereas the control group (n = 67) did not receive any intervention. Attention and executive functions, verbal memory, working memory, phonological fluency, category fluency and clinical variables were assessed at baseline and 6 months.

Results: Trail Making Test B execution time showed a decreased of -12.08 s (95% CI: -23.99, -0.18; p = 0.047) in the intervention group compared to the control group, after adjusting for age, educational level, time elapsed from the beginning of menopause and daily energy consumption (Cohen's d = -0.343). Attention, immediate or delayed verbal memory, phonological or category fluency, and working memory remained unchanged.

Conclusions: The consumption of cocoa-rich (99%) chocolate in addition to the habitual diet could be related to a slight improvement in cognitive performance regarding cognitive flexibility and processing speed in postmenopausal women, with no changes in the rest of the cognitive performance variables evaluated.Trial registration: This clinical trial has been registered at clinicaltrials.gov as NCT03492983.

Keywords: Chocolate; attention; cognition; executive function; memory; polyphenols; postmenopause.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Blood Pressure
  • Cacao*
  • Chocolate* / analysis
  • Cognition
  • Female
  • Humans
  • Middle Aged
  • Polyphenols / pharmacology
  • Postmenopause

Substances

  • Polyphenols

Associated data

  • ClinicalTrials.gov/NCT03492983