Embracing diversity: how can broadly neutralizing antibodies effectively target a diverse HIV-1 reservoir?

Andrew Wilson; Rebecca M Lynch

doi:10.1016/j.coph.2020.10.004

Embracing diversity: how can broadly neutralizing antibodies effectively target a diverse HIV-1 reservoir?

Curr Opin Pharmacol. 2020 Oct:54:173-178. doi: 10.1016/j.coph.2020.10.004. Epub 2020 Nov 12.

Authors

Andrew Wilson¹, Rebecca M Lynch²

Affiliations

¹ Department of Microbiology, Immunology and Tropical Medicine, The George Washington University School of Medicine & Health Sciences, Washington DC, USA.
² Department of Microbiology, Immunology and Tropical Medicine, The George Washington University School of Medicine & Health Sciences, Washington DC, USA. Electronic address: rmlynch@gwu.edu.

PMID: 33189993
DOI: 10.1016/j.coph.2020.10.004

Abstract

Genetic diversity in the latent proviral reservoir of HIV-1 infected individuals poses a challenge to cure strategies. It has become increasingly evident that diversity increases proportionally with length of active infection, and that functional and/or sterilizing cure strategies will need to overcome this obstacle in individuals who initiated antiretroviral therapy (ART) during chronic infection. Analyzing the results of analytic treatment interruption (ATI) has allowed for the evaluation of such therapeutic strategies in HIV+ individuals. Strategies to overcome the genetic diversity of the HIV-1 reservoir include antibody combinations, pre-screening individuals for bNAb sensitivity, focusing on low-diversity individuals as well as targeting host proteins.

Publication types

Review

MeSH terms

Animals
Broadly Neutralizing Antibodies / therapeutic use*
Genetic Variation
HIV Infections / drug therapy*
HIV Infections / genetics
HIV-1 / genetics*
Humans

Substances

Broadly Neutralizing Antibodies