On an extended understanding of the term "hormesis" for denoting alternating directions of the organism's response to increasing adverse exposures

Boris A Katsnelson; Vladimir G Panov; Ilzira A Minigalieva; Tatyana V Bushueva; Vladimir B Gurvich; Larisa I Privalova; Svetlana V Klinova; Marina P Sutunkova

doi:10.1016/j.tox.2020.152629

On an extended understanding of the term "hormesis" for denoting alternating directions of the organism's response to increasing adverse exposures

Toxicology. 2021 Jan 15:447:152629. doi: 10.1016/j.tox.2020.152629. Epub 2020 Nov 12.

Authors

Boris A Katsnelson¹, Vladimir G Panov², Ilzira A Minigalieva³, Tatyana V Bushueva³, Vladimir B Gurvich³, Larisa I Privalova³, Svetlana V Klinova³, Marina P Sutunkova³

Affiliations

¹ The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russia. Electronic address: bkaznelson@etel.ru.
² The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russia; Institute of Industrial Ecology, The Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.
³ The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russia.

PMID: 33189796
DOI: 10.1016/j.tox.2020.152629

Abstract

The authors propose to consider as hormesis phenomenon not only a realization of the Arndt-Schulze rule but any non-monotonic dose-response relationship for a certain outcome that is characterized by changing direction of a response between adjacent ranges of doses of an initiator of this response, the number of such ranges being two or more. This approach is illustrated with results of several in vitro experiments on different established cell lines exposed to CdS or PbS nanoparticles.

Keywords: Monotonic; dependencies; dose-response; hormesis; non-monotonic.

Publication types

Review

MeSH terms

Animals
Cadmium Compounds / administration & dosage
Cadmium Compounds / toxicity*
Dose-Response Relationship, Drug
Hormesis / drug effects
Hormesis / physiology*
Humans
Lead / administration & dosage
Lead / toxicity*
Models, Theoretical*
Myocytes, Cardiac / drug effects
Myocytes, Cardiac / physiology*
Nanoparticles / administration & dosage
Nanoparticles / toxicity*
Sulfides / administration & dosage
Sulfides / toxicity*

Substances

Cadmium Compounds
Sulfides
cadmium sulfide
lead sulfide
Lead