The relationship between depressive symptoms, general psychopathology, and well-being in patients with major depressive disorder

J Clin Psychol. 2021 Jun;77(6):1472-1486. doi: 10.1002/jclp.23083. Epub 2020 Nov 14.

Abstract

Objective: In mental health care, treatment effects are commonly monitored by symptom severity measures. This study aimed to investigate the relationship between symptom severity and well-being in the treatment of patients with major depressive disorder (MDD).

Methods: Adult MDD outpatients (n = 77) were administered the Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR), the Outcome Questionnaire (OQ-45), and the Mental Health Continuum-Short Form (MHC-SF) before treatment and 6 months later.

Results: Symptom severity correlated moderately with well-being at baseline and strongly at follow-up. Reliable change index scores showed improvement on the QIDS-SR, OQ-45, and MHC-SF in 65%, 59%, and 40%, respectively. A quarter of patients improved in symptom severity but not well-being (Inventory of Depressive Symptomatology-Self-Report [IDS-SR]: 25%; OQ-45: 24%).

Conclusion: Findings suggest that symptom severity and subjective well-being are related, but distinct concepts. Several reasons for the stronger improvements in symptoms than in well-being are discussed.

Keywords: Mental Health Continuum-Short Form; Routine Outcome Monitoring; depression; dual continua model; well-being.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Depression
  • Depressive Disorder, Major* / therapy
  • Humans
  • Psychiatric Status Rating Scales
  • Psychopathology
  • Self Report
  • Surveys and Questionnaires