Complete, Unpredictable, Multi-site Response Including Brain and Liver Metastases in a Patient With RET-rearranged Non-small-cell Lung Cancer Treated With Single-agent Immunotherapy: A Case Report

Clin Lung Cancer. 2021 Mar;22(2):e215-e219. doi: 10.1016/j.cllc.2020.10.011. Epub 2020 Oct 21.
No abstract available

Keywords: Immune-checkpoint inhibitors; NSCLC; Oncogenic drivers; Predictive biomarkers; RET rearrangement.

Publication types

  • Case Reports

MeSH terms

  • Brain Neoplasms / genetics
  • Brain Neoplasms / secondary
  • Brain Neoplasms / therapy*
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Carcinoma, Non-Small-Cell Lung / secondary
  • Carcinoma, Non-Small-Cell Lung / therapy*
  • Female
  • Gene Rearrangement
  • Humans
  • Immune Checkpoint Inhibitors / therapeutic use
  • Immunotherapy*
  • Liver Neoplasms / genetics
  • Liver Neoplasms / secondary
  • Liver Neoplasms / therapy*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Lung Neoplasms / therapy*
  • Middle Aged
  • Proto-Oncogene Proteins c-ret / agonists
  • Proto-Oncogene Proteins c-ret / genetics*
  • Treatment Outcome

Substances

  • Immune Checkpoint Inhibitors
  • Proto-Oncogene Proteins c-ret
  • RET protein, human