Co-inspired hydroxyapatite-based scaffolds for vascularized bone regeneration

Chun Feng; Jianmin Xue; Xiaopeng Yu; Dong Zhai; Rongcai Lin; Meng Zhang; Lunguo Xia; Xiaoya Wang; Qingqiang Yao; Jiang Chang; Chengtie Wu

doi:10.1016/j.actbio.2020.11.010

Co-inspired hydroxyapatite-based scaffolds for vascularized bone regeneration

Acta Biomater. 2021 Jan 1:119:419-431. doi: 10.1016/j.actbio.2020.11.010. Epub 2020 Nov 10.

Authors

Chun Feng¹, Jianmin Xue¹, Xiaopeng Yu¹, Dong Zhai¹, Rongcai Lin², Meng Zhang¹, Lunguo Xia³, Xiaoya Wang¹, Qingqiang Yao², Jiang Chang¹, Chengtie Wu⁴

Affiliations

¹ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China.
² Department of Orthopaedic Surgery, Digital Medicine Institute, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, PR China.
³ Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, PR China.
⁴ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address: chengtiewu@mail.sic.ac.cn.

PMID: 33181360
DOI: 10.1016/j.actbio.2020.11.010

Abstract

Hydroxyapatite (HA) is the main inorganic component of human bone. Inspired by nacre and cortical bone, hydroxyapatite-based coil scaffolds were successfully prepared. The scaffolds presented "brick and mortar" multi-layered structure of nacre and multi-layered concentric circular structure of cortical bone. Because of bioactive components and hierarchical structure, the scaffolds possessed good compressive strength (≈95 MPa), flexural strength (≈161 MPa) and toughness (≈1.1 MJ/m³). In addition, they showed improved angiogenesis and osteogenesis in rat and rabbit critical sized bone defect models. By mimicking co-biological systems, this work provided a feasible strategy to optimize the properties of traditional tissue engineering biological materials for vascularized bone regeneration.

Keywords: Biomimetic material; Co-inspired; Hydroxyapatite-based; Vascularized bone regeneration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Regeneration*
Bone and Bones
Durapatite*
Osteogenesis
Porosity
Rabbits
Rats
Tissue Engineering
Tissue Scaffolds

Substances

Durapatite