Assessment of delayed diagnosis and treatment in multiple sclerosis patients during 1990-2016

Acta Neurol Belg. 2021 Feb;121(1):199-204. doi: 10.1007/s13760-020-01528-7. Epub 2020 Nov 12.

Abstract

Multiple sclerosis (MS) is the most common inflammatory demyelinating disease in the central nervous system. It is one of the major causes of disability in young adults. Early diagnosis and treatment of this disease could decrease later disability and additional costs. In this cross-sectional analytical study, a total of 351 patients were selected from among the multiple sclerosis patients that went to MS clinic or neurologic clinic in 1990-2016. Data were collected and analysed by SPSS v16. This study was conducted on 82.6% females and 17.4% males. Family history of MS was positive in 12.8% of cases. Mean time of onset of symptoms till first medical visit was 3.25 months. Mean time from first medical visit to diagnosis was 14.98 months. Mean time from onset of symptoms till diagnosis was 18.01 months and the mean time from onset of symptoms till initiation of treatment was 18.73 months. Also, 29.3% of cases had delay in first medical visit and 42.2% of cases had delay in diagnosis of MS more than 6 weeks from first medical visit. Overall, delay in first medical visit and diagnosis of MS has decreased over the years. However, there is still delay in diagnosis of MS. Factors associated with delay are low education, male gender, living in rural areas, primary progressive MS, age at MS diagnosis and first clinical symptoms.

Keywords: Age at disease onset; Delayed diagnosis; Multiple sclerosis.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Delayed Diagnosis / prevention & control
  • Delayed Diagnosis / trends*
  • Disease Progression*
  • Female
  • Humans
  • Iran / epidemiology
  • Male
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / epidemiology*
  • Multiple Sclerosis / therapy
  • Treatment Outcome
  • Young Adult