Bridging the gap - a new role for STAT3 in TLR4-mediated metabolic reprogramming

Immunol Cell Biol. 2021 Feb;99(2):122-125. doi: 10.1111/imcb.12414. Epub 2020 Nov 11.

Abstract

Balic et al. describe a new role for STAT3 in TLR4 signalling in macrophages, linking LPS mediated activation of this innate immune receptor to phosphorylation of mitochondrial STAT3, resulting in distinct metabolic reprogramming.

Publication types

  • Comment

MeSH terms

  • Animals
  • Lipopolysaccharides*
  • Macrophages / metabolism
  • Mice
  • Mice, Knockout
  • STAT3 Transcription Factor / metabolism
  • Signal Transduction
  • Toll-Like Receptor 4* / metabolism

Substances

  • Lipopolysaccharides
  • STAT3 Transcription Factor
  • Tlr4 protein, mouse
  • Toll-Like Receptor 4