Frequencies of CD33+CD11b+HLA-DR-CD14-CD66b+ and CD33+CD11b+HLA-DR-CD14+CD66b- Cells in Peripheral Blood as Severity Immune Biomarkers in COVID-19

Ricardo Wesley Alberca; Milena Mary de Souza Andrade; Anna Cláudia Calvielli Castelo Branco; Anna Julia Pietrobon; Nátalli Zanete Pereira; Iara Grigoletto Fernandes; Luana de Mendonça Oliveira; Franciane Mouradian Emidio Teixeira; Danielle Rosa Beserra; Emily Araujo de Oliveira; Sarah Cristina Gozzi-Silva; Yasmim Álefe Leuzzi Ramos; Cyro Alves de Brito; Marcelo Arnone; Raquel Leao Orfali; Valeria Aoki; Alberto Jose da Silva Duarte; Maria Notomi Sato

doi:10.3389/fmed.2020.580677

Frequencies of CD33+CD11b+HLA-DR-CD14-CD66b+ and CD33+CD11b+HLA-DR-CD14+CD66b- Cells in Peripheral Blood as Severity Immune Biomarkers in COVID-19

Front Med (Lausanne). 2020 Oct 14:7:580677. doi: 10.3389/fmed.2020.580677. eCollection 2020.

Authors

Ricardo Wesley Alberca¹, Milena Mary de Souza Andrade¹, Anna Cláudia Calvielli Castelo Branco^{1

2}, Anna Julia Pietrobon^{1

2}, Nátalli Zanete Pereira¹, Iara Grigoletto Fernandes¹, Luana de Mendonça Oliveira^{1

2}, Franciane Mouradian Emidio Teixeira^{1

2}, Danielle Rosa Beserra¹, Emily Araujo de Oliveira¹, Sarah Cristina Gozzi-Silva², Yasmim Álefe Leuzzi Ramos¹, Cyro Alves de Brito³, Marcelo Arnone⁴, Raquel Leao Orfali¹, Valeria Aoki¹, Alberto Jose da Silva Duarte⁵, Maria Notomi Sato¹

Affiliations

¹ Laboratorio de Dermatologia e Imunodeficiencias (LIM-56), Departamento de Dermatologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.
² Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
³ Technical Division of Medical Biology, Immunology Center, Adolfo Lutz Institute, São Paulo, Brazil.
⁴ Departamento de Dermatologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.
⁵ Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Abstract

Common clinical features of patients with Coronavirus disease-2019 (COVID-19) vary from fever, to acute severe respiratory distress syndrome. Several laboratory parameters are reported as indicators of COVID-19 severity. We hereby describe the possible novel severity biomarkers for COVID-19, CD11b+CD33+HLA-DR-CD14+ cells and CD11b+CD33+HLA-DR-CD66b+ cells.

Keywords: COVID-19; SARS-CoV-2; biomarker; infection; severity.