Multiple Therapy Approach for Stage 3 Coats Disease: Long-Term Follow-Up

Rodolfo Mastropasqua; Rossella D'Aloisio; Paulo Eduardo Stanga; Richard Haynes

doi:10.1155/2020/8840630

Multiple Therapy Approach for Stage 3 Coats Disease: Long-Term Follow-Up

J Ophthalmol. 2020 Oct 26:2020:8840630. doi: 10.1155/2020/8840630. eCollection 2020.

Authors

Rodolfo Mastropasqua^{1

2}, Rossella D'Aloisio³, Paulo Eduardo Stanga⁴, Richard Haynes¹

Affiliations

¹ Bristol Eye Hospital, Bristol, UK.
² Institute of Ophthalmology, University of Modena and Reggio Emilia, Modena 41121, Italy.
³ Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti 66100, Italy.
⁴ School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Abstract

Purpose: To assess long-term efficacy of a multiple therapy approach in the treatment and management of unilateral stage 3 Coats disease with exudative retinal detachment.

Methods: 2 eyes of 2 young patients suffering from unilateral stage 3 Coats disease underwent a multiple therapy approach consisting of surgical drainage of exudative subretinal fluid + one simultaneous and up to one subsequent intravitreal injection of bevacizumab + multiple (up to 3) laser photocoagulation sessions of retinal nonperfusion areas and leaking Coats vasculature.

Results: Complete reabsorption of SRF and retinal reattachment were observed in both cases over the follow-up. In no cases, we observed progression to phthisis bulbi. No bevacizumab-related complications were observed. Epiretinal membrane onset was detected in one eye at the end of follow-up.

Conclusion: The management and treatment of this rare and degenerative disease in young subjects are still a challenge. The described technique is less invasive than conventional intraocular surgery and may be preferable to halt the devastating progression of the disease.