SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs

Paul R Wosniok; Christopher Knopf; Sandra Dreisigacker; J Manuel Orozco-Rodriguez; Bettina Hinkelmann; Peter P Mueller; Mark Brönstrup; Dirk Menche

doi:10.1002/chem.202003845

SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs

Chemistry. 2020 Nov 26;26(66):15051. doi: 10.1002/chem.202003845. Epub 2020 Nov 11.

Authors

Paul R Wosniok^{1

2}, Christopher Knopf^{1

3}, Sandra Dreisigacker^{1

4}, J Manuel Orozco-Rodriguez⁵, Bettina Hinkelmann⁵, Peter P Mueller⁵, Mark Brönstrup⁵, Dirk Menche¹

Affiliations

¹ Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, 53121, Bonn, Germany.
² Current address: Eurofins Umwelt West GmbH Wesseling, Vorgebirgsstrasse 20, 50389 Wesseling, Germany.
³ Current address: Eurofins Umwelt West GmbH Wesseling, Eurofins Genomics Europe Synthesis GmbH, Anzinger Str. 7a, 85560 Ebersberg, Germany.
⁴ Current address: HWI pharma services GmbH, Rheinzaberner Straße 8, 76761, Ruelzheim, Germany.
⁵ Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124, Braunschweig, Germany.

PMID: 33174290
DOI: 10.1002/chem.202003845

Abstract

Invited for the cover of this issue is the group of Dirk Menche at the University of Bonn. The image depicts the natural product leupyrrin A₁ and a synthetic leupylog in balance on an IC50 weighing scale. Read the full text of the article at 10.1002/chem.202002622.