Hematological changes in patients with COVID‑19 (Review)

Mol Med Rep. 2020 Dec;22(6):4485-4491. doi: 10.3892/mmr.2020.11581. Epub 2020 Oct 11.

Abstract

In December 2019, an emergence of pneumonia was detected in patients infected with a novel coronavirus (CoV) in Wuhan (Hubei, China). The International Committee on Taxonomy of Viruses named the virus severe acute respiratory syndrome‑CoV‑2 and the disease CoV disease‑19 (COVID‑19). Patients with COVID‑19 present with symptoms associated with respiratory system dysfunction and hematological changes, including lymphopenia, thrombocytopenia and coagulation disorders. However, to the best of our knowledge, the pathogenesis of COVID‑19 remains unclear. Therefore, understanding the mechanisms underlying the hematological changes that manifest during COVID‑19 may aid in the development of treatments and may improve patient prognosis.

Publication types

  • Review

MeSH terms

  • Antibodies, Viral / immunology
  • Antigen-Antibody Complex / immunology
  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use
  • Betacoronavirus* / immunology
  • COVID-19
  • COVID-19 Drug Treatment
  • Cellular Microenvironment
  • Coronavirus Infections / blood*
  • Coronavirus Infections / complications
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / therapy
  • Cytokine Release Syndrome / blood
  • Cytokine Release Syndrome / etiology
  • Cytokine Release Syndrome / prevention & control
  • Cytokines / blood
  • Diagnostic Tests, Routine
  • Endothelium, Vascular / pathology
  • Hematologic Tests
  • Hematopoiesis / drug effects
  • Hematopoietic Stem Cells / pathology
  • Humans
  • Hypoalbuminemia / etiology
  • Liver / physiopathology
  • Lung / physiopathology
  • Lymphopenia / etiology
  • Lymphopenia / physiopathology
  • Pandemics
  • Pneumonia, Viral / blood*
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / therapy
  • Reperfusion Injury / etiology
  • SARS-CoV-2
  • Thrombocytopenia / etiology
  • Thrombocytopenia / physiopathology
  • Thrombophilia / etiology

Substances

  • Antibodies, Viral
  • Antigen-Antibody Complex
  • Antiviral Agents
  • Cytokines