Ocular Manifestations of Sarcoidosis in a South Florida Population

Diana Laura; Yonghoon Lee; Monika Farhangi; Oriana Salamo; Mehdi Mirsaeidi; Raquel Goldhardt; Anat Galor

doi:10.2147/OPTH.S278373

Ocular Manifestations of Sarcoidosis in a South Florida Population

Clin Ophthalmol. 2020 Nov 2:14:3741-3746. doi: 10.2147/OPTH.S278373. eCollection 2020.

Authors

Diana Laura^{1

2}, Yonghoon Lee^{1

2}, Monika Farhangi^{1

2}, Oriana Salamo¹, Mehdi Mirsaeidi^{1

3}, Raquel Goldhardt^{1

2}, Anat Galor^{1

2}

Affiliations

¹ Miami Veterans Administration Medical Center, Miami, FL 33125, USA.
² Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL 33136, USA.
³ Department of Pulmonology, University of Miami, Miami, FL 33125, USA.

Abstract

Objective: To describe the ocular manifestations of sarcoidosis in a South Florida population and identify risk factors for the presence of ocular disease.

Design: Retrospective consecutive case series.

Methods: Medical charts of individuals with sarcoidosis seen in the University of Miami pulmonary department were reviewed for ocular disease. Odds ratios were used to identify risk factors for ocular sarcoidosis.

Results: Fourteen of 108 individuals with sarcoidosis had ocular involvement. The mean age of the 14 individuals was 56±15 years. Seventy-one percent were female, 50% were black, and 21% were Hispanic. Twelve had uveitis of which panuveitis was the most common subtype. Five had ≤20/70 vision in at least one eye due to uveitis. Neurosarcoidosis was a risk factor for ocular sarcoidosis (OR 6.14, p=0.03, 95% CI 1.21-31.09).

Conclusion: Ocular manifestations occurred in a minority of individuals in a pulmonary sarcoidosis clinic in South Florida. Uveitis was the most common ocular manifestation. Neurosarcoidosis was a risk factor for ocular involvement.

Keywords: neurosarcoidosis; ocular sarcoidosis; sarcoidosis; uveitis.

Grants and funding

Supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences R&D (CSRD) I01 CX002015 (Dr. Galor) and Biomedical Laboratory R&D (BLRD) Service I01 BX004893 (Dr. Galor), Department of Defense Gulf War Illness Research Program (GWIRP) W81XWH-20-1-0579 (Dr. Galor) and Vision Research Program (VRP) W81XWH-20-1-0820 (Dr. Galor), National Eye Institute R01EY026174 (Dr. Galor) and R61EY032468 (Dr. Galor), NIH Center Core Grant P30EY014801 (institutional) and Research to Prevent Blindness Unrestricted Grant (institutional).