Dispatching Sonic: A Eukaryotic RND Family Protein in the Hedgehog Signaling Cascade

Simon Newstead

doi:10.1016/j.devcel.2020.10.003

Dispatching Sonic: A Eukaryotic RND Family Protein in the Hedgehog Signaling Cascade

Dev Cell. 2020 Nov 9;55(3):255-256. doi: 10.1016/j.devcel.2020.10.003.

Author

Simon Newstead¹

Affiliation

¹ Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. Electronic address: simon.newstead@bioch.ox.ac.uk.

PMID: 33171107
DOI: 10.1016/j.devcel.2020.10.003

Abstract

A study in this issue of Developmental Cell (Petrov et al., 2020) provides evidence that eukaryotic RND proteins function as cholesterol transport systems in the Hedgehog signaling pathway, driven by either sodium or potassium gradients.

Publication types

Comment

MeSH terms

Cations
Cholesterol
Eukaryota*
Hedgehog Proteins* / genetics
Signal Transduction

Substances

Cations
Hedgehog Proteins
Cholesterol