Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescents

Andrea L Zaenglein; Moise L Levy; Nicole S Stefanko; Latanya T Benjamin; Anna L Bruckner; Keith Choate; Brittany G Craiglow; John J DiGiovanna; Lawrence F Eichenfield; Peter Elias; Philip Fleckman; Leslie P Lawley; Richard A Lewis; Anne W Lucky; Erin F Mathes; Leonard M Milstone; Amy S Paller; Sonali S Patel; Dawn H Siegel; Joyce Teng; Sherry A Tanumihardjo; Lauren Thaxton; Mary L Williams; PeDRA Use of Retinoids in Ichthyosis Work Group

doi:10.1111/pde.14408

Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescents

Pediatr Dermatol. 2021 Jan;38(1):164-180. doi: 10.1111/pde.14408. Epub 2020 Nov 10.

Authors

Andrea L Zaenglein¹, Moise L Levy², Nicole S Stefanko³, Latanya T Benjamin⁴, Anna L Bruckner⁵, Keith Choate⁶, Brittany G Craiglow⁶, John J DiGiovanna⁷, Lawrence F Eichenfield⁸, Peter Elias⁹, Philip Fleckman¹⁰, Leslie P Lawley¹¹, Richard A Lewis¹², Anne W Lucky¹³, Erin F Mathes^{9

14}, Leonard M Milstone⁶, Amy S Paller¹⁵, Sonali S Patel¹⁶, Dawn H Siegel¹⁷, Joyce Teng¹⁸, Sherry A Tanumihardjo¹⁹, Lauren Thaxton²⁰, Mary L Williams¹⁴; PeDRA Use of Retinoids in Ichthyosis Work Group

Affiliations

¹ Departments of Dermatology and Pediatrics, Penn State/Hershey Medical Center and Penn State Children's Hospital, Hershey, PA, USA.
² Departments of Pediatrics and Medicine, Division of Dermatology, Dell Medical School, University of Texas at Austin and Dell Children's Medical Center, Austin, TX, USA.
³ Division of Dermatology, Children's Hospital of Wisconsin, Milwaukee, WI, USA.
⁴ Department of Integrated Medical Science, Florida Atlantic University, Boca Raton, FL, USA.
⁵ Department of Dermatology, University of Colorado School of Medicine, Aurora, CO, USA.
⁶ Department of Dermatology, Yale University, New Haven, CT, USA.
⁷ Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, National Institutes of Health, Bethesda, MD, USA.
⁸ Departments of Dermatology and Pediatrics, University of California San Diego and Rady Children's Hospital, San Diego, CA, USA.
⁹ Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.
¹⁰ Department of Medicine, Division of Dermatology, University of Washington, Seattle, WA, USA.
¹¹ Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA.
¹² Departments of Ophthalmology, Molecular and Human Genetics, Medicine and Pediatrics, Baylor College of Medicine, Houston, TX, USA.
¹³ Department of Pediatrics, Division of Dermatology, Cincinnati Children's Hospital, Cincinnati, OH, USA.
¹⁴ Departments of Dermatology and Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
¹⁵ Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
¹⁶ Department of Pediatrics, Section of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA.
¹⁷ Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA.
¹⁸ Department of Dermatology, Stanford University, Stanford, CA, USA.
¹⁹ Department of Nutritional Sciences, University of Wisconsin, Madison, WI, USA.
²⁰ Department of Women's Health, University of Texas at Austin Dell Medical School, Austin, TX, USA.

Abstract

Topical and systemic retinoids have long been used in the treatment of ichthyoses and other disorders of cornification. Due to the need for long-term use of retinoids for these disorders, often beginning in childhood, numerous clinical concerns must be considered. Systemic retinoids have known side effects involving bone and eye. Additionally, potential psychiatric and cardiovascular effects need to be considered. Contraceptive concerns, as well as the additive cardiovascular and bone effects of systemic retinoid use with hormonal contraception must also be deliberated for patients of childbearing potential. The Pediatric Dermatology Research Alliance (PeDRA) Use of Retinoids in Ichthyosis Work Group was formed to address these issues and to establish best practices regarding the use of retinoids in ichthyoses based on available evidence and expert opinion.

Keywords: adverse drug effects; bone health; contraception; depression; disorder of cornification; drug monitoring; ectropion; hyperlipidemia; iPLEDGE; ichthyosis; quality of life; retinoid; safety monitoring; systemic therapy; topical therapy.

MeSH terms

Adolescent
Child
Consensus
Humans
Ichthyosis* / drug therapy
Ichthyosis, Lamellar*
Retinoids

Substances

Retinoids

Abstract

MeSH terms

Substances

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