Bacille Calmette-Guérin Vaccine-induced Osteomyelitis in Immunocompetent Children: A 10-year Case Series in Lithuania

Pediatr Infect Dis J. 2021 Feb 1;40(2):e77-e81. doi: 10.1097/INF.0000000000002981.

Abstract

The Bacille Calmette-Guérin (BCG)-induced osteomyelitis is an extremely rare systemic adverse reaction after BCG vaccination in immunocompetent children and the correct diagnosis is frequently missed. We present 4 clinical cases of BCG-induced osteomyelitis reported over a 10-year period in a high-TB incidence country Lithuania. A brief review of clinical, management and treatment features of the disease is given.

Publication types

  • Case Reports

MeSH terms

  • Antitubercular Agents / therapeutic use*
  • BCG Vaccine / adverse effects*
  • Child
  • Female
  • Humans
  • Immunocompetence
  • Infant
  • Lithuania / epidemiology
  • Male
  • Osteomyelitis / drug therapy
  • Osteomyelitis / etiology*
  • Osteomyelitis / microbiology*
  • Osteomyelitis / pathology

Substances

  • Antitubercular Agents
  • BCG Vaccine