Outcomes of fertility investigations in a cohort of adults with perinatally acquired HIV-1 infection: a UK cross-sectional observational study

Thomas J Pasvol; Jhia Teh; Danai Balfoussia; Rebecca Hall; Claire Petersen; Maryam Khan; Sara Ayres; Channa N Jayasena; Caroline Foster; Sarah Fidler

doi:10.1097/QAD.0000000000002745

Outcomes of fertility investigations in a cohort of adults with perinatally acquired HIV-1 infection: a UK cross-sectional observational study

AIDS. 2021 Feb 2;35(2):343-345. doi: 10.1097/QAD.0000000000002745.

Authors

Thomas J Pasvol^{1

2

3}, Jhia Teh¹, Danai Balfoussia^{2

4}, Rebecca Hall^{1

2}, Claire Petersen^{1

2}, Maryam Khan¹, Sara Ayres², Channa N Jayasena^{2

4}, Caroline Foster², Sarah Fidler^{1

2}

Affiliations

¹ Clinical Trials Centre, Winston Churchill Wing, St Mary's Hospital, Imperial College London.
² Imperial College Healthcare NHS Trust, London.
³ Research Department of Primary Care and Population Health, University College London.
⁴ Department of Andrology, Hammersmith Hospital & Section of Investigative Medicine, Imperial College London, UK.

Abstract

There are no published studies of fertility measurements in people living with perinatally acquired HIV (PaHIV). We performed fertility investigations in 25 adults with PaHIV. Seven (78%) men had sperm morphology normal forms (%) below the fifth centile for the general population with four (44%) having no normal forms. Mean (SD) serum anti-Müllerian hormone level was 19.4 (9.5) pmol/l; lower than expected for this age group. A larger study is needed to verify our findings.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cross-Sectional Studies
Female
Fertility
HIV Infections* / complications
HIV Seropositivity*
HIV-1*
Humans
Male
United Kingdom / epidemiology