Salivary flow, amylase, and total protein in hospitalized patients with HIV infection / AIDS complications

Afr Health Sci. 2020 Jun;20(2):597-604. doi: 10.4314/ahs.v20i2.7.

Abstract

Background: Saliva is a complex secretion produced daily by the salivary glands. Saliva consists mainly of water, enzymes, ions and amino acids and performs several important functions in oral health.

Objective: The aim of this study was to investigate the flow rate and concentrations of amylase and total proteins in the saliva of hospitalized patients due to AIDS complications.

Methods: Ninety-three men and women (20-64 years of age) were divided into two groups (46 HIV-infected patients and 47 controls) and had salivary flow rate and levels of amylase enzyme and total proteins evaluated.

Result: The mean salivary flow rate was lower in individuals with HIV when compared to controls (P < 0.05). No significant difference between amylase enzyme levels and total proteins were observed in the saliva of patients with HIV infection when compared to controls.

Conclusion: Individuals with HIV / AIDS infection (in hospital treatment) suffer no interference in levels of amylase and total salivary proteins, but they have significantly reduced salivary flow.

Keywords: Alpha-Amylases; Saliva; Salivary Proteins and Peptides; Salivation; Xerostomia.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Amylases / analysis
  • Amylases / metabolism
  • Anti-HIV Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active / adverse effects
  • Case-Control Studies
  • Female
  • HIV Infections / blood
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • HIV Seropositivity / complications*
  • HIV Seropositivity / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Saliva / metabolism*
  • Salivary Glands / metabolism
  • Salivary Proteins and Peptides / analysis
  • Salivary Proteins and Peptides / metabolism*
  • Salivation / physiology*
  • Secretory Rate / drug effects
  • Secretory Rate / physiology
  • Xerostomia / complications*
  • Xerostomia / etiology
  • Young Adult
  • alpha-Amylases / analysis
  • alpha-Amylases / metabolism*

Substances

  • Anti-HIV Agents
  • Salivary Proteins and Peptides
  • Amylases
  • alpha-Amylases