Disseminated Varicella-zoster Virus Infection Causing Fatal Pneumonia in an Immunocompromised Patient with Chronic Interstitial Pneumonia

Intern Med. 2021 Apr 1;60(7):1077-1082. doi: 10.2169/internalmedicine.5396-20. Epub 2020 Nov 9.

Abstract

Viral pneumonia caused by varicella-zoster virus (VZV) infection is a rare but important complication, especially regarding varicella infections. Although disseminated cutaneous herpes zoster (DCHZ) is often associated with visceral diseases, there have been few reports of DCHZ-related pneumonia. We herein report a rare case of a lethal disseminated VZV infection that caused severe pneumonia in a Japanese patient who had chronic interstitial pneumonia. Physicians should consider the possibility of VZV-related pneumonia, especially in patients with a medical history of hematopoietic stem cell transplantation and immunosuppressive therapy.

Keywords: chronic interstitial pneumonia; disseminated cutaneous herpes zoster; myelodysplastic syndrome; varicella-zoster virus; viral pneumonia.

Publication types

  • Case Reports

MeSH terms

  • Antiviral Agents / therapeutic use
  • Chickenpox* / drug therapy
  • Herpes Zoster* / complications
  • Herpes Zoster* / diagnosis
  • Herpes Zoster* / drug therapy
  • Herpesvirus 3, Human
  • Humans
  • Immunocompromised Host
  • Lung Diseases, Interstitial* / complications
  • Lung Diseases, Interstitial* / diagnosis
  • Pneumonia* / drug therapy

Substances

  • Antiviral Agents