Age-related Brain Morphological Alteration of Medication-naive Boys With High Functioning Autism

Abstract

Rationale and objective: To investigate age-related brain morphological changes of boys with high functioning autism (HFA).

Materials and methods: Forty-six medication-naive boys with HFA and 48 age-matched typically developing boys (4-12 years old) were included in this study. Structural brain images were processed with FreeSurfer to calculate the brain morphometric features including regional volume, surface area, average cortical thickness, and Gaussian curvature. General linear model was used to identify significant effects of diagnosis and age-by-diagnosis interaction. Correlations between age and the brain morphometric variables of significant clusters were explored.

Results: Primarily, most of the regions with statistically significant intergroup differences were located in the temporal lobe gyri. Importantly, the volume of bilateral superior temporal gyrus (STG) and the average cortical thickness of the right STG demonstrated significantly age-related intergroup differences. Further age-stratified analysis also revealed morphological alterations of STG among subgroups of preschool and school-aged children with or without HFA.

Conclusion: The findings demonstrated abnormal age-related volume and cortical thickness atrophy of the STG in HFA children, which reflect brain development trajectories of ASD may initiate to diverge from early overgrowth in childhood period. The anatomical localization of specific brain regions would help us better understand the neurobiology alterations of HFA patients and indicate the effect of age should be carefully delineated and examined in future studies about HFA.

Keywords: Age; Autism spectrum disorder; Cortical thickness; Regional brain volume; Structural MRI.