Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases

Trends Immunol. 2020 Dec;41(12):1128-1140. doi: 10.1016/j.it.2020.10.003. Epub 2020 Nov 4.

Abstract

Hematopoiesis is responsible for numerous functions, ranging from oxygen transportation to host defense, to injury repair. This process of hematopoiesis is maintained throughout life by hematopoietic stem cells and requires a controlled balance between self-renewal, differentiation, and quiescence. Disrupting this balance can result in hematopoietic malignancies, including anemia, immune deficiency, leukemia, and lymphoma. Recent work has shown that FBOX E3 ligases, a substrate recognition component of the ubiquitin proteasome system (UPS), have an integral role in maintaining this balance. In this review, we detail how FBOX proteins target specific proteins for degradation to regulate hematopoiesis through cell processes, such as cell cycle, development, and apoptosis.

Keywords: FBOX proteins; hematopoiesis; ubiquitin E3 ligases; ubiquitin proteasome system.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • F-Box Proteins / metabolism
  • Hematopoiesis* / genetics
  • Hematopoietic Stem Cells
  • Humans
  • Proteasome Endopeptidase Complex / metabolism
  • Proteolysis*
  • Ubiquitin / metabolism
  • Ubiquitin-Protein Ligases* / metabolism

Substances

  • F-Box Proteins
  • Ubiquitin
  • Ubiquitin-Protein Ligases
  • Proteasome Endopeptidase Complex