Abstract
Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent role of TCF1 in peripheral T cells, particularly during disease-induced inflammatory states such as autoimmunity, cancer, and chronic infections. Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies.
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autoimmune Diseases / drug therapy
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Autoimmune Diseases / immunology*
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Cell Communication / drug effects
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Cell Communication / immunology
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Cell Differentiation / genetics
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Cell Differentiation / immunology
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Chromatin Assembly and Disassembly / drug effects
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Chromatin Assembly and Disassembly / immunology
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Chronic Disease / drug therapy
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Disease Models, Animal
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Gene Expression Regulation / drug effects
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Gene Expression Regulation / immunology
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Humans
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Immunologic Factors / pharmacology
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Immunologic Factors / therapeutic use
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Immunologic Memory / drug effects
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Immunologic Memory / genetics
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Neoplasms / drug therapy
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Neoplasms / immunology*
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T Cell Transcription Factor 1 / metabolism*
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
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Virus Diseases / drug therapy
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Virus Diseases / immunology*
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Wnt Signaling Pathway / drug effects
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Wnt Signaling Pathway / genetics
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Wnt Signaling Pathway / immunology
Substances
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Immunologic Factors
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T Cell Transcription Factor 1