Dynamic light scattering imaging

Sci Adv. 2020 Nov 6;6(45):eabc4628. doi: 10.1126/sciadv.abc4628. Print 2020 Nov.

Abstract

We introduce dynamic light scattering imaging (DLSI) to enable the wide-field measurement of the speckle temporal intensity autocorrelation function. DLSI uses the full temporal sampling of speckle fluctuations and a comprehensive model to identify the dynamic scattering regime and obtain a quantitative image of the scatterer dynamics. It reveals errors in the traditional theory of laser Doppler flowmetry and laser speckle contrast imaging and provides guidance on the best model to use in cerebral blood flow imaging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural