Standardization of lower extremity quantitative lymphedema measurements and associated patient-reported outcomes in gynecologic cancers

Sandra Russo; Joan L Walker; Jay W Carlson; Jeanne Carter; Leigh C Ward; Allan Covens; Edward J Tanner 3rd; Jane M Armer; Sheila Ridner; Sandi Hayes; Alphonse G Taghian; Cheryl Brunelle; Micael Lopez-Acevedo; Brittany A Davidson; Mark V Schaverien; Sharad A Ghamande; Michael Bernas; Andrea L Cheville; Kathleen J Yost; Kathryn Schmitz; Barbara Coyle; Jeannette Zucker; Danielle Enserro; Stephanie Pugh; Electra D Paskett; Leslie Ford; Worta McCaskill-Stevens

doi:10.1016/j.ygyno.2020.10.026

Standardization of lower extremity quantitative lymphedema measurements and associated patient-reported outcomes in gynecologic cancers

Gynecol Oncol. 2021 Feb;160(2):625-632. doi: 10.1016/j.ygyno.2020.10.026. Epub 2020 Nov 4.

Authors

Sandra Russo¹, Joan L Walker², Jay W Carlson³, Jeanne Carter⁴, Leigh C Ward⁵, Allan Covens⁶, Edward J Tanner 3rd⁷, Jane M Armer⁸, Sheila Ridner⁹, Sandi Hayes¹⁰, Alphonse G Taghian¹¹, Cheryl Brunelle¹², Micael Lopez-Acevedo¹³, Brittany A Davidson¹⁴, Mark V Schaverien¹⁵, Sharad A Ghamande¹⁶, Michael Bernas¹⁷, Andrea L Cheville¹⁸, Kathleen J Yost¹⁹, Kathryn Schmitz²⁰, Barbara Coyle²¹, Jeannette Zucker²², Danielle Enserro²³, Stephanie Pugh²⁴, Electra D Paskett²⁵, Leslie Ford²⁶, Worta McCaskill-Stevens²⁷

Affiliations

¹ National Cancer Institute, Division of Cancer Prevention, 9609 Medical Center Drive, Rockville, MD 20892-9785, USA. Electronic address: sandra.russo@nih.gov.
² Stephen Cancer Center, OUHSC, Oklahoma City, OK 73104, USA. Electronic address: joan-walker@ouhsc.edu.
³ Cancer Research for Ozarks, 1235 E. Cherokee, Springfield, MO 65804, USA. Electronic address: jay.carlson@mercy.net.
⁴ Memorial Sloan Kettering Cancer Center, 641 Lexington Avenue, New York, NY, 10022, USA. Electronic address: carterj@mskcc.org.
⁵ University of Queensland, St Lucia, Brisbane, QLD 4072, Australia. Electronic address: l.ward@uq.edu.au.
⁶ University of Toronto and Sunnybrook Health Science Centre, Toronto, ON M4N 3M5, Canada. Electronic address: al.covens@sunnybrook.ca.
⁷ Northwestern Medicine, Feinberg School of Medicine, Prentice Women's Hospital, 250 E Superior, Chicago, IL 60611, USA. Electronic address: edward.tanner@nm.org.
⁸ Sinclair School of Nursing, University of Missouri Health, DC 116.05, Ellis Fischel Cancer Center, 115 Business Loop 70 West, Columbia, MO 65203, USA. Electronic address: armer@missouri.edu.
⁹ Vanderbilt University School of Nursing, 461 21st Ave South, Nashville, TN 37240, USA. Electronic address: sheila.ridner@vanderbilt.edu.
¹⁰ Queensland University of Technology, School of Public Health and Biomedical Innovation, Queensland, Australia. Electronic address: sc.hayes@qut.edu.au.
¹¹ Harvard Medical School/Massachusetts General Hospital, Radiation Oncology, Boston, MA 02114, USA. Electronic address: ataghian@mgh.harvard.edu.
¹² Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, MA 02114, USA. Electronic address: cbrunelle@mgh.harvard.edu.
¹³ The George Washington University Hospital, School of Medicine and Health Sciences, 2150 Pennsylvania Ave, NW, Washington, DC 20037, USA. Electronic address: mlopezacevedo@mfa.gwu.edu.
¹⁴ Duke University School of Medicine, Duke Cancer Center, 20 Duke Medical Center, Durham, NC 27710, USA. Electronic address: brittany.davidson@duke.edu.
¹⁵ The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: mvschaverien@mdanderson.org.
¹⁶ Augusta University, Augusta Oncology, 3696 Wheeler Road, Augusta, GA 30909, USA. Electronic address: sghamande@augusta.edu.
¹⁷ TCU and UNTHSC School of Medicine, Forth Worth, TX 76207, USA. Electronic address: mbernas@tcu.edu.
¹⁸ Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. Electronic address: cheville.andrea@mayo.edu.
¹⁹ Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. Electronic address: yost.kathleen@mayo.edu.
²⁰ Penn State Cancer Institute, 400 University Drive, Hershey, PA 17033, USA. Electronic address: kzs95@psu.edu.
²¹ Patient Advocate, Lymphedema Advocacy Group, Minneapolis, MN, USA.
²² National Lymphedema Network, 411 Lafayette Street, 6th Floor, New York, NY 10003, USA. Electronic address: jeannette.zucker@lymphnet.org.
²³ NRG Oncology Statistics and Data Management Center, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA. Electronic address: enserrod@nrgoncology.org.
²⁴ NRG Oncology Statistics and Data Management Center, 1600 JFK Blvd, Suite 1020, Philadelphia, PA 1903, USA. Electronic address: pughs@nrgoncology.org.
²⁵ The Ohio State University, 1590 N High Street, Suite 525, Columbus, OH 43210, USA. Electronic address: electra.paskett@osumc.edu.
²⁶ National Cancer Institute, Division of Cancer Prevention, 9609 Medical Center Drive, Rockville, MD 20892-9785, USA. Electronic address: fordl@mail.nih.gov.
²⁷ National Cancer Institute, Division of Cancer Prevention, 9609 Medical Center Drive, Rockville, MD 20892-9785, USA. Electronic address: wm57h@nih.gov.

Abstract

Practice changing standardization of lower extremity lymphedema quantitative measurements with integrated patient reported outcomes will likely refine and redefine the optimal risk-reduction strategies to diminish the devastating limb-related dysfunction and morbidity associated with treatment of gynecologic cancers. The National Cancer Institute (NCI), Division of Cancer Prevention brought together a diverse group of cancer treatment, therapy and patient reported outcomes experts to discuss the current state-of-the-science in lymphedema evaluation with the potential goal of incorporating new strategies for optimal evaluation of lymphedema in future developing gynecologic clinical trials.

Keywords: Gynecologic cancers; Lymphedema; Oncologic surgical treatment; Patient reported outcomes; Quantitative measurements.

Published by Elsevier Inc.

Publication types

Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Review

MeSH terms

Anthropometry / methods*
Chemotherapy, Adjuvant / adverse effects
Dielectric Spectroscopy / methods
Dielectric Spectroscopy / standards
Female
Genital Neoplasms, Female / complications
Genital Neoplasms, Female / therapy*
Gynecologic Surgical Procedures / adverse effects
Humans
Lower Extremity / pathology*
Lymph Node Excision / adverse effects
Lymphedema / diagnosis*
Lymphedema / etiology
Lymphedema / pathology
Lymphedema / therapy
Organ Size
Patient Reported Outcome Measures*
Radiotherapy, Adjuvant / adverse effects
Risk Factors
Sentinel Lymph Node Biopsy / adverse effects
Treatment Outcome

Abstract

Publication types

MeSH terms

Grants and funding