CircRNAs and LncRNAs in Osteoporosis

Tiantian He; Wei Liu; Lihua Cao; Ying Liu; Zi Zou; Yancheng Zhong; Haihua Wang; Yuqing Mo; Shuping Peng; Cijun Shuai

doi:10.1016/j.diff.2020.10.002

CircRNAs and LncRNAs in Osteoporosis

Differentiation. 2020 Nov-Dec:116:16-25. doi: 10.1016/j.diff.2020.10.002. Epub 2020 Oct 28.

Authors

Tiantian He¹, Wei Liu², Lihua Cao¹, Ying Liu¹, Zi Zou¹, Yancheng Zhong¹, Haihua Wang¹, Yuqing Mo¹, Shuping Peng³, Cijun Shuai⁴

Affiliations

¹ NHC Key Laboratory of Carcinogenesis of Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China; The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Non Resolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, 410011, Changsha, Hunan, People's Republic of China.
³ NHC Key Laboratory of Carcinogenesis of Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China; The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Non Resolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: shuping@csu.edu.cn.
⁴ Jiangxi University of Science and Technology, Ganzhou, 341000, China; State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha, 410083, China. Electronic address: shuai@csu.edu.cn.

PMID: 33157509
DOI: 10.1016/j.diff.2020.10.002

Abstract

Osteoporosis is a systemic bone disease with bone fragility and increased fracture risk. The non-coding RNAs (ncRNAs) have appeared as important regulators of cellular signaling and pertinent human diseases. Studies have demonstrated that circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) are involved in the progression of osteoporosis through a variety of pathways, and are considered as targets for the prophylaxis and treatment of osteoporosis. Based on an in-depth understanding of their roles and mechanisms in osteoporosis, we summarize the functions and molecular mechanisms of circRNAs and lncRNAs involved in the progression of osteoporosis and provide some new insights for the prognosis, diagnosis and treatment of osteoporosis.

Keywords: CircRNAs; LncRNAs; Osteoclastogenesis; Osteogenesis; Osteoporosis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bone Density / genetics
Bone and Bones / cytology
Disease Progression
Humans
Macrophages / immunology
Osteogenesis / genetics*
Osteoporosis / genetics*
Osteoporosis / pathology
RNA, Circular / genetics*
RNA, Long Noncoding / genetics*

Substances

RNA, Circular
RNA, Long Noncoding