Enhanced expression of angiotensin-converting enzyme 2 in psoriatic skin and its upregulation in keratinocytes by interferon-γ: implication of inflammatory milieu in skin tropism of SARS-CoV-2

Br J Dermatol. 2021 Mar;184(3):577-579. doi: 10.1111/bjd.19670. Epub 2020 Dec 28.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adult
  • Angiotensin-Converting Enzyme 2 / analysis
  • Angiotensin-Converting Enzyme 2 / metabolism*
  • COVID-19 / pathology
  • COVID-19 / virology
  • Case-Control Studies
  • Cells, Cultured
  • Female
  • Humans
  • Interferon-gamma / metabolism*
  • Keratinocytes / immunology
  • Keratinocytes / pathology
  • Keratinocytes / virology
  • Male
  • Primary Cell Culture
  • Psoriasis / immunology*
  • Psoriasis / pathology
  • SARS-CoV-2 / immunology*
  • Serine Endopeptidases / analysis
  • Serine Endopeptidases / metabolism
  • Skin / immunology
  • Skin / pathology*
  • Skin / virology
  • Spike Glycoprotein, Coronavirus / metabolism
  • Up-Regulation
  • Viral Tropism / immunology

Substances

  • IFNG protein, human
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • Interferon-gamma
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2
  • Serine Endopeptidases
  • TMPRSS2 protein, human