Variant analysis of 1,040 SARS-CoV-2 genomes

PLoS One. 2020 Nov 5;15(11):e0241535. doi: 10.1371/journal.pone.0241535. eCollection 2020.

Abstract

The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral genome is an RNA virus consisting of approximately 30,000 bases. As part of testing efforts, whole genome sequencing of human isolates has resulted in over 1,600 complete genomes publicly available from GenBank. We have performed a comparative analysis of the sequences, in order to detect common mutations within the population. Analysis of variants occurring within the assembled genomes yields 417 variants occurring in at least 1% of the completed genomes, including 229 within the 5' untranslated region (UTR), 152 within the 3'UTR, 2 within intergenic regions and 34 within coding sequences.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions
  • 5' Untranslated Regions
  • Betacoronavirus / genetics*
  • Genetic Linkage
  • Genome, Viral*
  • Linkage Disequilibrium
  • Lod Score
  • Mutation*
  • SARS-CoV-2
  • Sequence Analysis, RNA
  • Whole Genome Sequencing

Substances

  • 3' Untranslated Regions
  • 5' Untranslated Regions